Sentence examples for been difficult to construct from inspiring English sources

It has been difficult to construct a detailed 3'-UTR library from the schistosoma transcriptome because of an incomplete EST sequence, which has greatly inhibited extensive computational prediction of these miRNAs targets.

Since, these two residues have quite different conformational features, it would have been difficult to construct a holistic picture of electrostatic nature of the helix by attempting to integrate the effects due to these two.

However, targeted mutations in different regions of cipA have been difficult to construct by homologous recombination due to the presence of highly repeated DNA sequences within the gene.

Due to the narrow genetic base in cucumber, it has been difficult to construct high-density genetic maps from intra-varietal crosses to facilitate genetic mapping and QTL analysis of important traits (disease resistance, fruit yield etc).. To date, the most saturated intra-varietal map is constructed by Yang et al. with 735 SSRs and a mean marker interval of 0.96 cM [ 11].

It will be difficult to construct the high school.

This simulation task needs models, which are difficult to construct.

Indexes are difficult to construct and even harder to perfect, as studies have shown.

The sequence of events that occurred as the crust cooled is difficult to construct.

Perfect invisible cloak requires inhomogeneous and anisotropic media, however, it is difficult to construct by using natural materials.

Adapted coordinates are difficult to construct directly, without an appropriate singularly perturbed model of the dynamics.

'Social justice,' in particular, may be difficult to construct at a 'local' scale.