Sentence examples for been developed scheme from inspiring English sources
Recently, a multi-enzymatic synthesis for the manufacture of atorvastatin (Lipitor®), a cholesterol-lowering drug, has been developed (Scheme 1f) [ 21,22]: After asymmetric reduction of ethyl 4-chloroacetoacetate by an alcohol dehydrogenase (ADH), the obtained halohydrin was converted into the epoxide and further into the corresponding hydroxynitrile by a halohydrin dehalogenase.
Thus, an alternative procedure for inducing the polymerization of N-carbothiophenyl α-amino acids was developed (Scheme 8, method 2).
On the basis of these observations, a synthetic protocol for the targeted preparation of P5X2 +-cages was developed (Scheme 7).
NPP-caged coumarins that display more than 200-fold fluorescence enhancement upon UV irradiation were developed (Scheme 131).
Asymmetric diamination with chiral Cu(I) phosphate catalyst has also been shown to be viable, while more effective systems need to be developed (Scheme 26).
14a A two step procedure for the BINOL-catalyzed alkyne addition to aldehydes was developed (Scheme 8): (1) treatment of a terminal alkyne with ZnEt2 in refluxing toluene; (2) addition of (S -BINOL, Ti(OiPr)4, an aldehyde, and CH2Cl2.
On this basis a four-step synthesis of a broad array of monomers 1 a– r was developed (Scheme 1) exploiting either alkylation of the intermediate phenol at the diversification point using alkyl halides or alcohols under Mitsunobu conditions (i.e., 2 to 3 in Scheme 1).
Officials have been developing schemes to fortify New York's waterfront since Superstorm Sandy destroyed thousands of homes and businesses, and took more than 50 lives in the city, in 2012.
The Department of Construction was developing schemes for the building as early as 1948.
Radium was one of the first medical technologies funded by public appeals, and by the 1920s, in some regions and countries, specialists in radiotherapy were developing schemes for centralized treatment and research.
A whole simulator scheme has been developed for that purpose.
