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It has since been determined to function by inhibiting cAMP phosphodiesterases [ 91], and, as a consequence, levels of NAD+ increase with concomitant increased SIRT-1 activity.
In animals, CDK4/6 and cyclin D have been determined to function in the G1 phase, human CDK2 and cyclin A/E in S and G2 phases, and CDK1 and cyclin B in the M phase [ 5, 37].
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Beclin-1, an autophagy-promoting gene, was determined to function as a tumor suppressor after it was shown to be deleted in breast, ovarian, and prostate cancers.
The first characterized network gene, MAP3179c, was determined to function as a universal stress response gene that when bound to chromosomal DNA, initiates the SOS response.
Later, PuF was determined to also function as a kinase independently of its TF activity [ 91].
When expressions can be determined to be functioning in a specific disciplinary context then ambiguities tend to disappear.
The equilibrium adsorption level was determined to be a function of the solution pH, contact time, and sorbate concentration.
Three factors were determined to be the function of parameters, such as 2,4,6-TBP concentration (X1), initial pH value (X2) and the inoculum volume (X3).
He said: "I am determined to see a functioning executive in place at Stormont.
Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were determined to assess liver functions.
The ATPase activity and filamentous structure of the labelled proteins were determined to estimate their functions (Fig. S6).
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