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While a specific receptor for ESAT-6 has been identified using monocyte/macrophage cell lines [15], specific cell types to which ESAT-6/CFP-10 binds within a host have not previously been determined, particularly in the context of TB infection.
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Associations of bone mineral density (BMD) with specific food components, including dietary fiber and isoflavones (that have a negative association with serum estrogen), are unclear and need to be determined, particularly in populations more likely to consume large amounts of these nutrients (such as young athletes).
"Ends-in" and "ends-out" assessment was determined particularly in the case of CG4221 mutagenesis.
The cost effectiveness of this strategy would need to be determined, particularly in resource-limited settings.
Although it has beneficial effects in humans [ 9], long-term CR requires a major commitment of will power and its possible disadvantages remain to be determined, particularly in the elderly [ 10].
In addition, the interrelationships between PAH biomarkers must be determined, particularly when levels of the marker in surrogate molecules (e.g., protein) or markers from surrogate tissues (e.g., lymphocyte DNA) are used to assess the risk to the target organ, the lung.
The quantity of probiotic bacteria needed for optimum treatment of gastroenteritis remains to be determined, particularly when multiple species are included in the product.
Further, since the Ki-67 proliferative index was not routinely determined particularly in patients who were recruited early in this cohort, incomplete data restricted assessment of this parameter as a prognostic factor.
The depth of the ethnic and geographic origin data should be determined in advance, particularly in the case of small villages where carriers of rare variants could be identified even if personal information were not provided.
18 Because intent is often difficult to determine, particularly in deaths from poisoning, 19 and a considerable proportion of death certificates do not specify the drug(s) involved, 2 we defined our drug overdose outcome as any intentional, unintentional, or indeterminate overdose death caused by any medication or drug X40-455, Y10-15, Y10-15, without T-code specified).
Third, it is a group for which not only the HLA phenotype is available, but also the genotype, that is, the haplotypes were determined in each case, particularly in regard to class II genes.
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