Nominally significant associations were detected with several traits (Table 3).
Small levels of differential expression (ranging from 0.38-fold to 2.83-fold change in expression) were detected, with several hundred differentially expressed genes present in each grouping, with t scores above 6.
However, the fact that some genomic regions are detected with several selection tests does not really demonstrate the action of selection, but rather that the identified signal is strong enough to be picked up by various methods.
However much higher immunoreactivity was detected with several antibodies directed against the C-terminal part (115 140) of αS: these included LB509, produced against Lewy bodies (amino acid 115 122) and specifically recognizing the human protein, and 8A5 reported to be produced against 129 140 amino-acid and reacting with αS species in Lewy bodies [ 28].
A significant overlap was detected with several relevant gene families, including colon cancer progression (e.g., FN1, IGBP3, PLAUR and TIMP1; P=0.00052), tumour cell apoptosis (e.g., BID, TNFRSF21, PHLDA1 and NOTCH1; P=1.46 × 10 6) and cell proliferation (e.g., CTGF, SPP1, FOLR1 and SPARC).
A patient was considered to be infected with a helminth species, if the infection was detected with one or several diagnostic methods.
Furthermore, a gene environment interaction was detected with a combination of several gene variants (i.e., a haplotype) in the CRF1 gene (which also contains rs1876831) and childhood sexual abuse in a large cohort of Australians recruited for the Nicotine Genetics Project (Saccone et al. 2007).
This time several components were detected with UHPLC-PDA that have a clear yellow colour.
