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Since the discovery of collagenase in bone cells, more than half of the MMP members have been detected in bone tissues under both physiological and pathological conditions.
Its extracellular domain has been detected in bone marrow stromal cells [ 11, 12], heart, and spleen.
Furthermore, PUUV-specific RNA had never been detected in bone marrow.
Clonally related subpopulations of MPCs, sharing common IgH gene rearrangement, have been detected in bone marrow of MM patients.
Occult micrometastases have been detected in bone stromal aspirates from over 50%% of women at the time of primary breast cancer diagnosis [ 12– 15].
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No difference was detected in bone loss among the variables studied.
Notably, micro-metastases as small as 1.4 mm were detected in bone.
The aim of the present study was to determine whether Mycobacterium leprae could be detected in bone extracts, as a means of confirming the diagnosis of leprosy.
We also investigated whether arginase activation by diclofenac can be detected in bone marrow macrophage precursors.
Staining was detected in bone metastases sections from pimonidazole-labeled mice but not in control animals (Figure 1B).
Expression of the DMP1-caPTHR1 transgene was detected in bone tissues (L5 vertebra and tibia), but not in kidney, liver, spleen, heart, or brain (Figure 1B).
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