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Several antibodies have been designed to block ligands from binding to their respective TLRs.
The inhibitors of HIV-1 protease (PIs) have been designed to block the activity of the viral aspartyl-protease.
However, drugs that have been designed to block angiogenesis mainly capture growth factors in circulation, resulting not only in the transient inhibition of tumor progression but also in producing undesirable side effects.
Accordingly, several PD-1/PD-L1 blockers have been designed to block the interaction between PD-1 and PD-L1 to enable anti-tumour immunity.
To date, most of the therapeutics have been designed to block receptors and downstream signaling pathways, so inhibiting stroma-derived protumoral signals, such as the kinase inhibitor drugs.
Several agents, including small-molecule inhibitors of the tyrosine kinase activity of EGFR (EGFR-TKIs) and monoclonal antibodies (mAbs) specific for EGFR, have been designed to block EGFR signalling selectively (Ettinger, 2006; Harari and Huang, 2006; Imai and Takaoka, 2006).
Similar(53)
In fact it was designed to block a country.
Cybersitter is designed to block Web sites deemed to be pornographic, violent or offensive.
Drugs are being designed to block this kind of chain reaction.
*AstraZeneca's drug known as ZD1839 is designed to block a protein, epidermal growth factor.
"Antiretroviral drugs are designed to block H.I.V. replication, and they do that quite well," he said.
More suggestions(15)
been designed to work
been designed to optimize
been designed to blend
been designed to solve
been designed to assess
been designed to measure
been designed to read
been shown to block
been designed to accept
been designed to function
been used to block
been designed to speed
been designed to have
been designed to intimidate
been designed to extract
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com