The study was designed over a several year period and initiated in October 2012.
Our electrical grid was designed over a hundred years ago on a simple supply and demand model that assumes users will demand electricity and the grid will supply it.
Based on holistic control structure and MPC method, an objective function with constraints is designed over a receding horizon to meet the control requirements.
A chromatic corrector with two refractive diffractive hybrid elements is designed over a reasonable wide field-of-view of 7° to correct the chromatic aberrations of human eye.
The study was designed over a meso-scale (6200 km2), carried out in 2010 and repeated in 2012 on a subset of sites.
The exhibition center portion of the project was designed over a period of 14 months by Loschky Marquardt & Nesholm Architects while First & Goal managed the construction.
Primers and probes were designed over a conserved region of the genome and synthesized by Applied Biosystems.
This approach contrasts with the current method of using genome annotation to guide assay design, allowing a far greater number of assays to be designed over a wider proportion of the genome.
However, such studies should be designed over a period of 10 years or more and because of a high expected rate of relapsing patients and drop-outs they would require a very large sample size at baseline.
These properties include the absence of recombination, low effective population size and the conservative mutation rate, allowing for primers to be designed over a wide taxonomic range [ 34, 35].
