Biochemical potency depends on receptors that have been designed by evolution to be sensitive to subtle changes in chemical structure (for example estrogen vs. testosterone, or epinephrine vs. norepinephrine) whereas the hERG channel has been designed to transport potassium and has had little or no evolutionary pressure to be selective against micromolar concentrations of aromatic amines.
These compounds have been designed by evolution of previously described 2-aminohydroxamic acid PC-PLCBc inhibitors that block the enzyme by coordination of the zinc active site atoms present in PC-PLCBc [Gonzalez-Roura, A.; Navarro, I.; Delgado, A.; Llebaria, A.; Casas, J. Angew. Chem. Int. Ed. 2004, 43, 862].
Despite its ability to solve an array of problems, the slime mold was designed by evolution to solve just one problem: how to build an optimal transport network (for its nutrients).
They are trying to reshape psychology, placing at its center the question of how the mind was "designed" by evolution millions of years ago to solve specific problems faced by human ancestors in an environment very different from the modern world.
Put it this way: if panic attacks were designed by evolution to keep us safe from external enemies, channelling adrenalin to the heart, brain and muscles as a "fight or flight" response, then as we've evolved into modern humans, they have become the enemies.
The rituals survive despite seeming irrational because they are coded in parts of our brains, which are designed by evolution not to think about reasons.
We're designed by evolution to eat a wide variety of different things.
"This can be negative because we are designed by evolution to satiate and then stop eating but they are subverting that and making you eat more".
Because gene expression and methylation were designed by evolution to be sensitive to the environment, the transcriptome and epigenome could be useful as biomarkers of environmental change (Jirtle & Skinner, 2007; Mill & Petronis, 2008; Mill et al., 2008; Petronis, 2010), including prenatal experiences (Zhang & Meaney, 2010) and mother infant interaction (Champagne & Curley, 2009; Meaney, 2010).
Any machine or manufacturing process designed by engineers is not as excellent as alive organisms or processes carried out in natural surroundings, which have been designed by The NATURE in evolution process.
With anal, there's no such thing as parts sliding easily into other parts that have been designed by thousands of years of evolution/God (and I know how much all you guys love sticking things in each other's asses) to make the process easier by lubricating themselves automatically.
