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Nevertheless, some CocE mutants with an improved thermal stability have successfully been designed and discovered in recently reported studies, and these thermostable mutants did not decrease, or only slightly decreased, the catalytic efficiency (kcat/ KM) of CocE against cocaine.
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Primitive Tasp ase1 in hibitors (TASPINs) were designed and discovered, lending support to developing highly effective, specific Taspase1 inhibitors for cancer therapy.
This reaction does not have biologically analogous reactions and is a purely synthetic method that was designed and discovered in the organic research laboratory.
A series of phenoxyethylamine derivatives was designed and synthesized to discover potent and selective human α1D adrenoceptor (α1D adrenergic receptor; α1D AR) antagonists.
Twenty-eight novel 1,5-disubstituted-2(1H -pyridone derivatives were designed and synthesized for discovering more potent anti-lung cancer agents combined with anti-fibrotic profiles.
In a previously published study [ 3], this original strategy was designed and implemented to discover selective sweeps using two lightly genotyped (<200 K loci) human populations.
A questionnaire was designed and distributed to 100 students to discover their perception and collective experiences upon completing the online tasks.
However, most studies have been designed to discover associations between prenatal and perinatal conditions and DDE, molar-incisor hypomineralization or enamel hypoplasia in primary teeth [ 22– 24, 30, 31].
Many research projects have been designed to discover the disease occurrence pattern, resistance breeding and integrated control of the disease.
Although many successful algorithms have been designed to discover community structures in network, most of them are dedicated to disjoint and non-overlapping communities.
In recent years, several data mining based methods have been designed for discovering interesting patterns in event logs.
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