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Although one class of DNA transposon has been described with multiple genes and internal regulatory sequences, this element is more similar to a DNA virus (such as a herpes virus) than a transib element [47].
Very few families have been described with multiple affected individuals, but these have typically involved siblings (for example [ 47, 48]) where transmission occurs from asymptomatic mothers with skewed X-chromosome inactivation [ 48] or by parental gonadal mosaicism [ 49].
Different patterns of 99mTc-MIBI uptake have been described with multiple myeloma (negative, diffuse, focal, combined focal and diffuse) and semiquantitative evaluation of these patterns showed a significant correlation with clinical status and stage of the disease [ 20].
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Many progesterone receptor mRNA variants have been described with deletions of various whole, multiple or partial exons that encode differing protein functional domains.
Functional TREs have been described with a high level of degeneration, multiple spacer sizes and various half-site organizations [ 18, 49- 52] with a structure divergent from the models on which our identification algorithm was based.
While the INS cortex is generally included in the affective/motivational pathway, the role of the INS in salience detection and executive function is quite complex [ 14] and should deservedly be described with functions in multiple pain networks.
The differential SCN1A expression in rat myocardium might influence the susceptibility for sudden cardiac death in these children at different ages, since higher incidence of sudden death at young ages in patients with epilepsy has been described in multiple studies [27-30] [27-30]
Similar findings have been described in multiple other cell types treated with various pro-oxidants such as cisplatin [ 38] and thymoquinone [ 39].
Germline mutations in the cyclin-dependent kinase inhibitor, CDKN1 B, have been described in patients with multiple endocrine neoplasia (MEN), a cancer predisposition syndrome with adult onset neoplasia and no additional phenotypes.
Protons have been described to interact with multiple extracellular sites of nicotinic ACh receptors, decreasing the effective EC50 of the agonist and accelerating gating kinetics (1).
Immunomediated destruction of the transformed cells overexpressing survivin by cytotoxic T cells has been described in patients with multiple myeloma [ 24] and neuroblastoma [ 25], which may provide a plausible explanation for the extracellular appearance of survivin.
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