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A Candida gut infection model has also been described which allows disease progression across the gastrointestinal mucosa and subsequent systemic dissemination of the fungus to be investigated (MacCallum, 2012).
However, a mechanism that depends on p66Shc post-translational modifications, including serine phosphorylation by stress kinases like Jnk-1 and Pkc-B and prolilisomerization by Pin-1, has been described, which allows p66Shc increase within the mitochondria during apoptosis [ 22].
Finally, an alternative noninvasive method, the tensiomyography based solely on biomechanical parameters, has been described, which allows the determination of the myosin heavy chain I proportion in superficial human skeletal muscle [ 44].
In a more recent development, FlexMAP bead-coupled MLPA has been described, which allows for the simultaneous detection of 100 distinct sequences per reaction (identification of distinct sequences, which can all be the same size, is based on association with a distinct bead) [ 2] (See additional file 2: Diagram of bead-coupled MLPA).
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A semi-implicit time step method is described which allows violation of the Courant condition.
A straightforward extrapolation methods is described which allows the separation of faradaic impedances from measured spectra.
A novel class of photochromic devices is described which allows the user control over the photochromic response of the device.
A new technique is described which allows the direct measurement of static and dynamic holdup and axial dispersion coefficients in a packed extraction column.
A mathematical model is described which allows the optimisation of the spanwise lift distribution of a high speed craft with a criterion of maximal offwind speed.
A new electrochemical technique, Three Electrode Electrochemical Voltage Spectroscopy (TEVS) is described which allows detailed information to be derived for both intercalation electrodes within a single experiment.
A new method is described which allows separation of two-electrode polarization into individual anodic and cathodic polarizations of each electrode.
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