Sentence examples for been described to regulate from inspiring English sources
Although a number of intracellular negative regulators have been described to regulate TLR function (Kawai and Akira, 2010), to our knowledge, Siglecs constitute the first class of cell surface pattern recognition receptors that are directly involved in regulation of TLR function.
PKD has previously been described to regulate the activation of the integrin regulator Rap1 in the Jurkat T-cell line [ 27].
Recently, PAR-1 has been described to regulate the gap junction protein Connexin 43 and the maspin tumor suppressor gene to promote the metastatic melanoma phenotype.
Exosomes play an important role in intercellular communication and have been described to regulate immune functions, tumor migration and modulate the actions of drugs[32].
Similarly to MSCs, pericytes have been described to regulate T-cell activation, recruit T- and B-lymphocytes to areas of tissue injury[119, 120] and control transmigration of thymocytes from the thymus across the blood vessel wall[121].
Natural resistance associated macrophage protein 1 (NRAMP1), encoded by the SLC11A1 gene, has been described to regulate macrophage activation and be associated with infectious and autoimmune diseases.
Recently in E. coli, HU was described to regulate the expression of ∼8% of the genome [80].
Subsequently, it was described to regulate cell surface expression of TNFR-I [11], TNFR-II [12], Notch [13], Delta-like-1 [14], SCF [15], CD40 [16], L-selectin [17], CX3CL1 [18], LAG3 [19], Flt3L [20] and several other transmembrane proteins that are relevant to immune system development.
Interestingly, Mcl-1 was described to regulate intracellular Ca2+ homeostasis by interacting with IP3R.
The chemokine receptor 4 (CXCR4) was described to regulate the homing of lymphocytes in inflammatory tissues (Murdoch, 2000).
Only 62 of those random genes were found in the literature to be involved in cancer, among which 11 are described to regulate metastasis and 8 are linked to hypoxia.
