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This effect has been described mostly in the context of major depression, where immune-mediated activation of indoleamine 2,3-dioxygenase (IDO), the initial key enzyme of the kynurenine pathway, and related decrease in serotonin synthesis have been considered key elements of the pathophysiology [14 16].
Genetic polymorphisms along the vitamin D pathway have been described mostly in western populations.
To date, aUPD has been described mostly in hematologic malignancies, [ 12- 15] breast cancer [ 16- 18] and colon cancer [ 19].
In contrast, Alkhurma hemorrhagic fever is an emerging infectious disease that has been described mostly in Saudi Arabia.
Since that first report, an increasing number of cases have been described, mostly in the upper Midwest and in the Northeast regions of the United States (5 ).
The implementation of DSME and DSMS strategies and its potential positive effects have been described mostly in sophisticated health care settings in high income countries [ 4- 8].
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Tubulointerstitial nephritis and uveitis is an uncommon entity that is described mostly in children with a median age of diagnosis of 15 years and has a 3 1 female predominance [7, 8].
2 Leishmania siamensis infection was described mostly in acquired immunodeficiency syndrome (AIDS) patients from Thailand.
While negative effects of sleep disturbances on quality of life are well documented [ 35], the micturition/defecation disorders' effects are described mostly in surgical patients.
In the view of most of the participants, the clinical leader is described mostly in the context of hierarchical, positional leadership [ 33], such as a nurse manager where the process of organising a unit or ward (i.e., managing, making decisions, team building, communication) is emphasised.
Approximately 200 B. mandrillaris meningoencephalitis cases have been described, mostly from warm climate areas in South America.
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