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It is the commonest solid tumour of the newborn with a mean age at presentation of 3 months, although it has been described in older children and adults.
In addition to the electrophysiological phenotype, structural degeneration of the primary pacemaker, the SAN has been described in older Popdc1−/− and Popdc2−/− mice [ 6].
Most cases have been described in older, large breed intact male dogs [ 30- 32] that typically showed signs of tenesmus and dysuria due to encroachment of the colon and urethra by the cystic masses [ 31- 33], as was seen in the dog presented in this report.
For example, a fourfold increase in the risk of frailty has been described in older men and women with low vitamin D status [ 32] and a meta-analysis indicated that vitamin D supplementation (700 1000 IU/day) reduces risk of falls in older people [ 33].
We did observe a certain level of actin disorganization in the organization of actin in talpid embryos at stage 4HH which has previously been described in older talpid chicken embryos (Yin et al., 2009), suggesting that not all TALPID3 dependent function may be normal.
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In addition, changes in antibody specificity, isotype, affinity, and affinity maturation have been described in old age (Dailey et al 2001; Howard et al 2006).
Numerous medicinal plants have been described in old literature of Arabic traditional medicine for treatment of Alzheimer's disease (AD) (or to strengthen memory).
But most of these procedures have been described in children older than 3 years as they require patient cooperation.
Faecal shedding of M. avium in pigs has been described in the older literature by various authors [ 23- 25].
Interestingly, both amyloid plaque and reduced CSF Aβ have been described in some older adults with no clinical symptoms indicative of a cognitive impairment.
Functional incontinence has typically been described in frail older adults with mobility or cognitive impairment, and refers to the inability to reach the toilet in time to void [ 7].
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