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Relatively specific responses to CO2-enriched air mixtures have been described in controlled studies of PD and SAD.
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However, observed upregulation of ANKRD1 is very likely to be universal pathophysiological as it was described in controlled increased stretch states such as experimental pressure overload [ 5] and not due to genetic alterations.
Among the atypical antipsychotics, the use of risperidone and aripiprazole for the treatment of TS has been described in randomized controlled trials (RCTs) and case series studies [ 6– 12].
This phenomenon had been described in multiple randomized controlled trials of the effects of pneumococcal conjugate vaccines on nasopharyngeal colonization (16 ) but had never been described in the setting of invasive disease.
The power calculation of the randomized controlled trial has been described in a previous study [ 9].
The CiQ trial, which has been described in detail elsewhere, 6 is a randomised controlled trial of a five-session SCSO case-worker delivered smoking cessation intervention for socially disadvantaged smokers.
The design and the predictors of adherence to this randomised controlled trial have been described in more detail elsewhere [ 15, 23].
The design of this randomized, double-blind, parallel-group, dose-optimized, placebo-controlled study has been described in detail previously [ 15].
23 This manuscript presents data from a large randomised controlled study (RCT) which has been described in detail previously.
The intervention has been described in detail elsewhere [ 36] and will be evaluated within a non-randomised controlled trial.
These findings demonstrate that in young subjects with early, well-controlled T2D the incretin effect is reduced, similar to what has been described in diabetic adults.
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