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INTRODUCTION Primary sarcomas of the pancreas are rare, and the limited data regarding their presentation, oncologic profile, and survival have been derived from small case series.

This intriguing and clinically highly relevant concept, however, has so far been derived from small case-control studies and patient series.

Previous estimates of fracture non-union have generally been derived from small cohorts of particular anatomical regions.

Studies used to derive gene expression signatures predictive of outcome or treatment response have frequently been derived from small and clinically heterogeneous patient series with validation and training tumours originating from the same patient cohorts.

While trace levels of GLUT5 mRNA may be present in the myocardium, because the total RNA in this study was isolated from whole tissue rather than isolated cardiomyocytes, it is possible that the low level detection of GLUTs 5 and 6 may have been derived from small amounts of other cell types harvested along with the left ventricle.

Several prediction equations that account for sex and/or age in converting weight and height to body fat have been published and are reasonably effective in overcoming the aforementioned problem, but they have been derived from small samples or from imprecise methods of measurement of body composition (10, 12– 12).

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For podoconiosis, such data have to date been derived from small-scale studies.

The somatic mutational landscape of cancer has to date largely been derived from small-scale or targeted approaches, leading to the discovery of genes affected by somatic mutations in many diverse cancer types.

However, all the clinical data available so far have been derived from small-scale clinical trials, and further validation for the treatment of vascular disease is needed, including larger sample sizes or multi-center clinical trials [ 41] (Table  1).

"Hydrogen-bonding criteria were derived from small molecule crystal studies and are similar to those used in an earlier study (Presta & Rose, 1988).

As a result, new generation of receptor proteins has been developed, that are derived from small and robust immunoglobulin (Ig) or non-immunoglobulin based "scaffolds".

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