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This new role of PGC-1β in mitochondrial physiology has been demonstrated using both in vitro (muscle cells) and in vivo (PGC-1β-ablated mice) approaches.
In Arabidopsis, the centromere-specific localization of CENH3 has already been demonstrated using both recombinant and immunocytological approaches [ 33, 47, 52, 53].
Robust and accurate mechanistic drug drug relationships have repeatedly been demonstrated using both simple correlation analysis and more sophisticated data analytical methods (Paull et al, 1989; Weinstein et al, 1992, 1997; Boyd and Paull, 1995).
The involvement of ADAMTS proteinases in connective tissue turnover has been demonstrated using both cleavage-epitope-specific antibodies and inhibitors that exclude the involvement of other proteinases, particularly the MMPs [ 3, 32].
The function of Siglec 2 (CD22) and Siglec-G in immune tolerance has also been demonstrated using both synthetic ligands and mice with deletions of the Cd22 and Siglecg genes (Duong et al., 2010; Jellusova et al., 2010; Pfrengle et al., 2013).
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The performance of this approach is demonstrated using both simulations and in vivo images.
The approach is demonstrated using both simulated results and practical measurements.
The effectiveness of the present FRF estimation technique is demonstrated using both simulated and experimental data.
The efficacy of the new discrete operators is demonstrated using both smooth and discontinuous test cases.
Toxicity of these compounds to live Anopheles gambiae was demonstrated using both tarsal contact (filter paper) and topical application protocols.
The performance of the proposed approach is demonstrated using both numerical models and experimental studies of composite laminates.
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