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Dr. Fisher believes it is triggered by higher levels of vasopressin and oxytocin, which have been demonstrated to trigger attachment in animals.
Among the proposed mechanisms accounting for the proapoptotic effect of anion channels, cellular acidification due to anion influx has been demonstrated to trigger mitochondria apoptotic cascade involving Bcl-2.
Although NMDA receptor stimulation has been demonstrated to trigger pannexin hemichannel opening in pyramidal neurons and drive epileptiform seizure activity [54], the relative contributions of NMDA and non-NMDA receptor signaling to the regulation of pannexin hemichannel gating in the retina remains unclear and constitutes an area of future investigation.
The oligomerization of amyloid peptides and AMPs have been demonstrated to trigger membrane leakage.
In tobacco, PVD358, PVD374 and PVD417 have all been demonstrated to trigger ISR [ 132].
In contrast, AMPK has been demonstrated to trigger adaptive responses in cancer cells under metabolically depressed states like hypoxia and low glucose conditions [ 14, 44].
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Studies of phase transitions and critical behaviour in non-Hermitian systems date back to the discovery of the Lee-Yang edge singularity1, where an imaginary magnetic field in the high-temperature Ising model was demonstrated to trigger an exotic phase transition.
The glycosylphosphatidylinositol (GPI) of T. gondii was demonstrated to trigger TLR4 signaling pathways [ 8– 10].
Meanwhile, microbial products such as LPS were demonstrated to trigger a program of DCs maturation which enables DCs to activate T cells [ 14].
One of these histone deacetylase inhibitors is suberoylanilide hydroxamic acid, which was demonstrated to trigger autophagy-associated cell death in apoptosis-deficient tumor cells, such as chondrosarcoma cells.
Kid was demonstrated to trigger apoptosis in HeLa cells with widespread cell death occuring beyond three days of Kid expression and total cell death after 15 days [ 19].
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