Previously, a combination of Hsp90 inhibitor geldanamycin and bortezomib was demonstrated to simultaneously disrupt Hsp90 and proteasome function, promote accumulation of ubiquitinated proteins, and enhance antitumour activity in human breast cancer cells (Mimnaugh et al, 2004, 2006).
The meso-limbic and orbito-frontal dopaminergic systems has also been demonstrated to be implicated by simultaneously measuring the fixation potential of 11C-raclopride, a D2/D3 agonist.
Enhancing matrix crystallization has been demonstrated to be an effective method to simultaneously improve the impact toughness and heat resistance of poly l-lactide) (poly l-lactide with flexible PLLAmodifiedch as poly(ε-caprolactone) (PCL).
Moreover, methods utilising several model outputs simultaneously have already been demonstrated to reduce the model sloppiness by imposing more constraints on the system 5.
Simultaneously, AEG-1 has been demonstrated to activate Wnt-mediated signaling in some malignant tumors.
Later, a combination of intramembranous and endochondral ossification was demonstrated to occur simultaneously within the regenerate in dog and sheep [31, 32, 33, 44, 45].
A multiplexed optical coupler composed of three FZP layers was demonstrated to couple three waveguides simultaneously in a waveguide array.
The 136A2 HyBeacon was demonstrated to be capable of simultaneously analysing at least three SNPs, generating four distinct melting peaks (table 2).
T. thermophilus was demonstrated to be capable to produce simultaneously two biotechnologically important bio-products; biodegradable biopolymers PHAs and RLs-type biosurfactants by utilizing either glucose or sodium gluconate as sole carbon source, although the ability to produce them, and especially RLs, is in fact restricted to a limited number of bacterial species (Abdel-Mawgoud et al. 2010).
It has been demonstrated that simultaneously targeting different opioid receptors is a more effective therapeutic strategy.
