For example, one "brain-specific" miRNA, miR-124 [ 29], was described in a number of reports and was demonstrated to shift the expression profiles of HeLa cells towards the brain signature [ 30, 31].
Using gene expression profiling and gene set enrichment analysis on breast cancer cell lines and breast cancer specimens, reducing FoxA1 expression has been demonstrated to cause a partial shift from luminal to basal gene signatures and basal cancer phenotypes.
This surface-fingerprint technique has been demonstrated to provide both qualitative (chemical shift) and quantitative (peak intensity) information on the concentration and distribution of truly surface features.
For example, substrate expression levels [ 81], as well as PS1 FAD mutations [ 59, 82- 84] have been demonstrated to effect a right-ward shift on in vitro potencies of gamma-secretase inhibitors.
With C214 as a prototype, molecular modifications are then made and a scheme, using NH groups to connect neighboring phenyls in the triphenylamine donor, has been demonstrated to be successful to significantly red-shift the absorption maximum wavelength, extend the lifetime of the first excited state, and decrease the energy gap between HOMO and LUMO.
Members of the medically important genus Echis exhibit considerable variation in venom composition, which has been demonstrated to co-evolve with evolutionary shifts in diet.
The binding is also demonstrated to shift the monomer-fibril equilibrium in favor of dissociation.
Second, it is important to note that thermotolerance is not the only phenotypic trait for which it has been demonstrated that a shift occurred within the native range of W. auropunctata between natural versus human-modified populations, and that native and introduced populations from human-modified habitats were phenotypically closer to each other than to natural populations from the native range.
It has been demonstrated that this shift can be modeled fairly well by taking into account the differences in absorption cross-section for different sizes of NCs.
It has been demonstrated that the shift in the amplitude ratio of the coupled-resonators at the in-phase mode-frequency, in response to a mass change, is five orders of magnitude greater than the equivalent resonant frequency shift of a single resonator device.
