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Furthermore, SPS model has been demonstrated to replicate the inner neuroendocrine abnormality associated with PTSD [ 43].
Both PUUV and HPS-related Sin Nombre virus have been demonstrated to replicate in pulmonary capillary endothelial cells, inducing inflammatory changes in the endothelium and capillary leakage that has been attributed to effects of vascular endothelial growth factor [ 11, 16, 17, 37- 40].
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The resulting RV-RabG constructs were demonstrated to replicate to high titers (8 log10 infectious particles/ml) in complementing helper cells.
During the subsequent verification steps, the construct was demonstrated to replicate with a copy number comparable to most other low-copy number plasmids.
These concentrations were chosen after calculating the ratio of the concentration used and the half-maximal effective concentration (EC50) provided by the drug company to achieve a ratio of GSK1016790A similar to the ratio used for capsaicin injections, because capsaicin was demonstrated to replicate analgesia according to the results of this study.
In those studies, the matrix keratinocytes were demonstrated to have the potential to replicate beyond that normally achieved.
In most cases, those genes bearing mutations that were demonstrated to be beneficial also harboured mutations in multiple replicate populations.
7 The strong and significant association of FLG null mutations with atopic eczema has been demonstrated and replicated in multiple case control, family- and population-based studies.
Taken together, these results provide a strong rationale for the clinical efficacy of nintedanib in IPF, which has recently been demonstrated in two replicate international phase III clinical trials.
It has subsequently been demonstrated that these regions replicate late in S phase [ 29].
Recently, it has been demonstrated that DV replicates and produces infectious virus in platelets [ 61].
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