Sentence examples for been demonstrated to physically from inspiring English sources
AP-1 has been demonstrated to physically interact with the GR to prevent binding to GREs 6, 67.
α-Synuclein has been demonstrated to physically interact with mitochondrial membranes, thereby interfering with mitochondrial function (Li et al, 2007; Cole et al, 2008; Chinta et al, 2010).
On one hand, pVHL, as a facilitating factor in colorectal oncogenesis, has been demonstrated to physically interact with KLF4 and promote KLF4 protein degradation (Gamper et al, 2012).
The Arabidopsis NDR1 protein has been demonstrated to physically interact with RIN4 both in a yeast heterologous system and in planta [ 24].
Oct4 has also been demonstrated to physically interact with Wdr5, a core member of the mammalian Trithorax complex, and cooperate in the transcriptional activation of self-renewal genes [ 36].
Intriguingly, IKKβ, a major downstream kinase in the TNFα-signaling pathway, has been demonstrated to physically interact with and phosphorylate TSC1, thereby suppressing TSC1, which results in mTORC1 activation.
A corresponding peptide (residues Lys158-Asp171, termed KKDC) was demonstrated to physically associate with heparin and HS, and to inhibit heparanase enzymatic activity.
Antibodies against the C-terminal region from T. cruzi ribosomal P proteins were demonstrated to physically interact, with an agonist effect, with human second loop of G-protein-coupled receptors.
Furthermore, nuclear EGFR has been demonstrated to interact physically with signal transducer and activator of transcription 3 (Stand) and E2F-1 [24], [24].
CD44 has also been demonstrated to interact physically and functionally with Mmp7 and Mmp9 in multiple cell types, and by doing so enhances the activities of Mmp7 and Mmp9 on specific substrates within the extracellular environment [ 66, 71- 73].
These 'greater good' perspectives are often buttressed in the literature by arguments that turn on the extent to which the individual who uptakes ART could benefit (or at least not suffer) as the short-term effects of the early initiation of ART have not been demonstrated to be physically detrimental [ 27].
