Kv4 channels have been demonstrated to interact with K-channel-interacting proteins and dipeptidyl peptidase-like type II proteins, DPP6 and DPP10 (reviewed by Vacher et al., 2008).
There are precedents for this possibility, as several other essential splicing factors have already been demonstrated to interact with each other through protein-protein interactions involving their RRMs [72], [73], [74].
SEU has been demonstrated to interact with AP1 and SEPALLATA3 (SEP3) to bridge the interaction between AP1/SEP3 and LUG in Arabidopsis (Sridhar et al., 2006) resulting in transcription repression during flower development.
According to the observation of "guilt by association", genes with similar functions have been demonstrated to interact with each other more closely in the protein-protein interaction (PPI) networks than those functionally unrelated genes [ 12].
In fact, Arf6-GTP has recently been demonstrated to interact with AP-2 both in vitro and in vivo, and a clathrin-interacting Arf6-specific GTPase activating protein (called SMAP), affecting clathrin-dependent endocytosis only, has also been identified (Paleotti et al. 2005; Tanabe et al. 2005).
DOI: http://dx.doi.org/10.7554/eLife.07888.018 Polo-box domains are crucial mediators of the interaction of Polo-like kinases with their targets and have been demonstrated to interact with irregular substrate peptides and phosphopeptides.
However, silver ions have been demonstrated to interact with the proteins and possibly phospholipids associated with the proton pump of bacterial membranes.
For instance, Au55 nanoparticles of 1.4-nm size have been demonstrated to interact with the major grooves of DNA which accounts for its toxicity [84].
Interestingly, FIP200, an ULK1-binding protein, has been demonstrated to interact with the TSC1/TSC2 complex through TSC1 [28].
Many of these proteins are regulators of the cytoskeleton, which have been demonstrated to interact with the nucleus.
Furthermore, the ethylene receptors themselves have been demonstrated to interact with each other to form higher-order receptor complexes [9], [29].
