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Phosphorylation has been demonstrated to functionally regulate most of Bcl2 family members.
Recently, it was discovered that activation of NALP3 in intestinal epithelial cells limits pathogen colonization and dampens the ensuing intestinal inflammation during the early course of infection, and the polymorphisms of NALP3 have been demonstrated to functionally link with the susceptibility to inflammatory disease [ 70 ▪].
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Orthologues of clr-1 and clr-2 have been identified in many fungal species but some of the orthologues have been demonstrated to be functionally different.
TCR-grafted T cells have been demonstrated to be functionally active both in vitro [18] and in vivo [19], [20].
This is the first single biomarker that has been demonstrated to be functionally involved in stem cell maintenance.
Human podocytes (Pods) have been demonstrated to be functionally and structurally injured in the natural history of diabetic nephropathy [ 2].
In bone, multiple P2X and P2Y receptors have been demonstrated to be functionally expressed by both osteoblasts and osteoclasts.
P2Y1 receptors have been demonstrated to be functionally expressed by Müller cells and microglial cells, rather than by neurons.
These two polymorphisms have been demonstrated to be functionally meaningful, resulting in increased transcriptional activity of HIF-1α [ 14, 18].
Both R1 and B1 are basic helix loop helix transcription factors that have been demonstrated to be functionally redundant in maize.
Therefore, we created chimeric Nup-fusions by replacing Nup98 FG repeats with those from hNup153FG (and.1118–1475) and hNup214FG (A.A.1605–2090), which have been demonstrated to be functionally exchangeable in experiments that addressed the transforming ability in NIH3T3 cells (Kasper et al., 1999).
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