Sentence examples for been demonstrated to downregulate from inspiring English sources

Among these miRNAs, miR-7 has been demonstrated to downregulate EGFR in different cancer cells.

Moreover, BMPs have been demonstrated to downregulate the mineralization process of cementoblasts.

For example, miR29b has been demonstrated to downregulate Mcl-1 protein and sensitize cells to apoptosis [ 44].

Skin whitening agents that activate MAPK phosphorylation have been demonstrated to downregulate MITF protein expression and inhibit tyrosinase-related protein synthesis and melanin production [ 24, 25, 28- 30].

The use of Nobiletin, a citrus bioflavonoid, has been demonstrated to downregulate both of the constitutive expressions of CXCR4 and MMP-9 in human breast cancer cells.

For example, IGF-I has been demonstrated to downregulate the progesterone receptor via a transcriptional mechanism that involves the PI3K/Akt pathway and is independent of the ER.

Rare codons placed near the N-terminus of the well-expressed protein eGFP were demonstrated to downregulate eGFP expression effectively, which is reflected in the eGFP fluorescence intensity (Fig. 4a).

A specific p38 inhibitor was demonstrated to downregulate the unwanted release of IL-6 after cooling and rewarming most effectively.

MiR-494 has been demonstrated to target and downregulate KIT thereby inhibiting GIST cell growth and inducing apoptosis (Kim et al, 2011).

In vitro metformin has also been demonstrated to induce apoptosis in human ovarian cancer cell lines by directly activating caspases 3/7, downregulating Bcl-2 and Bcl-xl expression, whereas upregulating Bax and Bad expression (Yasmeen et al, 2011).

A highly accessible site on this mRNA was identified, and a ribozyme targeted to this site was demonstrated to effectively downregulate NCOA3 function in cells.