Eculizumab has been demonstrated to block complement activation in the treatment of patients with paroxysmal nocturnal haemoglobinuria (PNH), in which red blood cells are lysed by complement due to an inherited lack of inhibitors on their cell surface, and is, therefore, approved for this application.
Only capsid proteins, 3CD, and 3D have been demonstrated to trans-complement (Novak and Kirkegaard, 1994; Nugent et al., 1999; Oh et al., 2009).
However, the levels of expression and functionality of these molecules could be different among T. cruzi strains, since resistance to complement killing has been demonstrated to vary among them [20], [24].
The complement system has been demonstrated to play a key role in the development of sepsis in rodents and humans [22], [23].
Complement mediated immunity has been demonstrated to be important for opsonisation of the bacteria for neutrophil phagocytosis and in systemic clearance of S. pneumoniae infection [12].
Inhibition or deficiency of other complement components have also been demonstrated to be effective in ameliorating injury, including inhibition of C1 by C1-inhibitor (C1-INH) [ 17], C4 deficiency or inhibition by C4 antibody [ 18], C5aR blockade [ 19], and factor B deficiency [ 20] or inhibition by factor B antibody [ 21].
As a complement to experiments, molecular dynamics (MD) simulation has been demonstrated to be one powerful tool to investigate the atomic scale phenomena of friction and wear [10 20].
The resulting RV-RabG constructs were demonstrated to replicate to high titers (8 log10 infectious particles/ml) in complementing helper cells.
If effective, pregabalin, whose beneficial effects on pain and sleep quality in fibromyalgia have been demonstrated, could complement the antidepressant and anxiolytic effects of trazodone.
The importance of the CC in HSPC homing has been demonstrated in complement component-deficient mice.
