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The upregulation of myocellular DGAT1 has been demonstrated to augment TAG storage, decrease cellular DAG, and protect against high fat diet induced IR (Liu et al. 2007).
For example, a combination of NF-κB inhibitor, such as parthenolide or curcumin, with PXL has been demonstrated to augment the therapeutic efficacy in various cancer models [5].
A brief exposure of skin to a low-power, non-tissue damaging laser light has been demonstrated to augment immune responses to intradermal vaccination.
Additionally, plasmid gene transfer of SDF-1 has been demonstrated to augment neovascularization through VEGF [ 50].
Inducible expression of rat MUC4 in human A375 melanoma cells has been demonstrated to augment primary tumor growth [ 25] and metastasis [ 26] in a nude mouse xenograft model.
An overexpression of c-Src in murine mesangial cells has been demonstrated to augment NF- κB activation and nitric oxide production [ 22].
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In addition, HBP was demonstrated to augment leukocyte adhesion to lung microvessel endothelial monolayers and induce significant monocyte migration into lungs [ 9, 23].
Effective targeting of Mcl-1 in TRAIL resistant GBM cells, either by gene silencing technology or by treatment with R-roscovitine, a cyclin-dependent kinase inhibitor that targets Mcl-1, was demonstrated to augment sensitivity to TRAIL, both within GBM cells grown as monolayers and in a 3D tumour model.
Various conventional chemotherapeutic agents have been demonstrated to synergistically augment TRAIL-induced apoptosis through induction of DR5 expression.
Apart from above applications, phosphate groups grafted to polymer backbones have also been demonstrated to improve function of osteoblast cells and augment performance of bone grafts (Sailaja et al. 2009; Xu et al. 2011).
Early enteral nutrition has been demonstrated to improve nitrogen balance, wound healing and host immune function, and to augment cellular antioxidant systems, decrease the hypermetabolic response to tissue injury and preserve intestinal mucosal integrity [ 1- 7].
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