Sentence examples for been demonstrated that stem from inspiring English sources

It has been demonstrated that stem cell-based periodontal regeneration is likely to produce more reliable and effective results in the management of periodontal defects, particularly of the large tissue defects caused by the disease.

It has also been demonstrated that stem cell markers like ALDH1, HIWI, Oct3/4, ABCG2, SOX2, SALL4, BMI-1, NANOG, CD133 and podoplanin are associated with patient's prognosis, pathological stages, cancer recurrence and therapy resistance.

It has been demonstrated that stem cells interact with supportive cells that function as a scaffold and help restore the structure and function at the target region in a number of body systems.

It was demonstrated that stem cells act through a dual mechanism: cell-to cell contact and modulation mediated by soluble factors produced by cells themselves.

For instance, it was demonstrated that stem-cell marker-negative cells were also able to grow as spheres and to give rise to very aggressively growing tumours in vivo.

It has been demonstrated that leukemia stem cells are heterogeneous in terms of their origins [11] and different leukemia stem cells can give rise to different types of leukemia [12], [13].

Over the last several years, it has been demonstrated that embryonic stem cells (ESCs) are able to differentiate into gametes [11] [18].

Recently, it has been demonstrated that hematopoietic stem cells are positive for SSEA-4 (and Sca1 positive but c-Kit/CD45/Flk-1/and SSEA-1 negative) both in mouse and in human and, in fact, SSEA-4 has been proposed to better purify HSCs from the bone marrow [58].

Moreover, we previously reported that the NEU4 overexpression enhances an undifferentiated stem cell-like phenotype and cell proliferation in human neuroblastoma cells and, recently, it has been demonstrated that mouse neural stem cells highly express NEU4.

Concordantly, it has been demonstrated that glioma cancer stem cells acquire resistance to radiotherapy through over-activation of the DNA damage checkpoint and repair response [85].

It has been demonstrated that mouse embryonic stem cells (mESCs) and mouse iPS cells have high basal levels of γH2AX, in a mechanism that is not dependent on DNA damage response.