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It has been demonstrated that persistent activation of NFĸB pathway caused muscle wasting [ 47].
It has been demonstrated that persistent activation of Rac1 in hepatic stellate cells can promote both fibrosis and liver injury in vivo [ 54].
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Since it has already been demonstrated that patients with persistent DTC have a poor prognosis [ 13- 15], determination of the bone marrow status after neoadjuvant chemotherapy might identify those patients at a high risk for metastatic disease and identify patients who may need secondary therapy.
It has been demonstrated that the attack of persistent vegetative state is associated with the damaged neuron, which produces dopamine, and nervous pathway, the reduce of dopamine or malfunction of dopamine.
However, it has been demonstrated that human macrophages support persistent transcription from unintegrated HIV-1 DNA [32] highlighting the role of unintegrated viral DNA.
It has been demonstrated that sustained activation of NTSR1 results in persistent NTSR1 recycling as well as signalization activation, including ERK1/2 [19], and causes sustained gene activation of MMP9 and Bcl-2 [8], [8].
29, 30 It has been demonstrated that the immune response in chronic HIV is down regulated by a genetic mechanism in the face of persistent infection.
Many studies have demonstrated that persistent microcirculation alterations that are unresponsive to therapy are independently associated with adverse outcome, especially in septic patients [1-5].
We demonstrated that persistent TCR signaling is required to sustain IL-2 production (Huppa et al., 2003) at all times.
Qualitative and quantitative analyses demonstrated that persistent abdominal distension was associated with the diagnosis of ovarian cancer (38 of 44 women with cancer).
In conclusion, our results demonstrated that persistent low sclerostin serum levels are associated with continuous inflammation in AS patients under anti-TNF therapy.
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