Sentence examples for been demonstrated that histone from inspiring English sources

Importantly, it has recently been demonstrated that histone modifications at an origin of replication serve as a binary switch for controlling the timing of replication of the Beta-globin locus in human [48].

It has also been demonstrated that histone modifications play significant role in the activity of EBV promoters and expression of viral proteins (Gerle et al. 2007; Countryman et al. 2008; Fejer et al. 2008).

It has been demonstrated that histone modifications are involved in gene regulation [ 42] so that a secreted Arabidopsis-like histone deacetylase would be an exciting example of how cyst nematodes could modify gene expression of their host plants and mimic plant proteins to interfere with the physiology of the host.

It has been demonstrated that the histone hyperacetylation induced by HDAC inhibitors causes structural alterations in chromatin, which may expose portions of DNA that are normally protected by heterochromatin to DNA-damaging agents, such as UV, cytotoxic drugs or ROS.

Encouraging progress in this endeavour has been made in recent years and it has been demonstrated that benzamide-based histone deacetylase inhibitors (HDACi) such as BML-210 and the related pimelic diphenylamides 4b and 106 have the ability to reactivate the silenced FXN gene in FRDA (Chou et al, 2008; Herman et al, 2006; Rai et al, 2008).

Specifically, it has been demonstrated that loss of histone H3K9, H3K27, and H4K20 trimethylation markedly impairs chromatin structure, diminishes the ability of the cells to regulate and maintain accurately the cell cycle, disrupts the balance between cell proliferation and differentiation, and severely reduces cell viability (Rea et al. 2000; Yang and Mizzen 2009).

It has also recently been demonstrated that evicted parental histones generally remain within about 400 bp of their original location when reincorporated (Radman-Livaja et al., 2011), crucial if the histone modifications are to be kept in register with the underlying DNA sequence.

For example, it has been demonstrated that DNMTs physically bind to several histone modifiers including histone deacetylases (HDACs) [6], [7], SUV39H1 [8] and EZH2 [9].

It has recently been demonstrated that the therapeutic use of histone deacetylase inhibitors in CC has a high anti-cancer potential [ 59].

It has also been demonstrated that Tax protein can recruit histone methyltransferase SUV39H1 to 5′LTR and induce H3K9 methylation whereby it modulates its own expression which plays a role in the regulation of viral latency (Kamoi et al. 2006).

It has also been demonstrated that post-translational modification of histones can control gene activity.