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It has been demonstrated that circulating IGFBP-4 is partially glycosylated in its N-terminal region, although the influence of this glycosylation on PAPP-A-mediated proteolysis and the ratio of glycosylated/non-glycosylated IGFBP-4 fragments in human blood remain unrevealed.
Similarly, it has been demonstrated that circulating CD146+ cells, which contain endothelial progenitors but also mature endothelial cells [34], may harbor the virus, too, in KS patients [16].
It has previously been demonstrated that circulating catecholamines are elevated [3] whilst renal blood flow is decreased, in patients with asymptomatic left ventricular dysfunction [23].
It has been demonstrated that circulating levels of growth hormone drop with increasing age.
It has been demonstrated that circulating markers of inflammation can be helpful in early diagnosis of surgical infection in the postoperative period.
It has been demonstrated that circulating monocytes relocate to the intestinal mucosa during intestinal inflammation, but the phenotype and inflammatory mechanisms of these monocytes remain poorly understood.
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By using rodent models of diabetes, obesity and hypertension, it was demonstrated that circulating succinate levels in these animals are elevated compared to non-diseased controls [ 31].
It was demonstrated that circulating levels of IL-10 increased in relation to elevated TNF- α levels in patients with dilated cardiomyopathy and may support the concept that the increase of IL-10 levels enhances the release of sTNFR2 [ 43].
It has been demonstrated that elevated circulating levels of free estrogen, as well as estrone and androgens, are associated with BC [ 34].
Rather, it has been demonstrated that the circulating hemocytes in the flies are primarily of embryonic and larval origin (Holz et al., 2003; Honti et al., 2014).
Interestingly, it has been demonstrated that whereas circulating DCs isolated from patients with cancer are deficient in their function, DCs conditioned in vitro in the absence of tumor products have the capacity to induce robust immune responses [ 9, 10].
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