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It has been demonstrated, in model neurons, in slice preparations, and in whole brains, that neural synchronization is facilitated by the addition of optimal amounts of random fluctuations, or "noise," to a neural network, whereas less than optimal amounts have less effect and larger than optimal amounts destroy synchronization [3].
Hence, removal of senescent cells is beneficial and has been demonstrated in model animals [ 84].
Although complete dosage compensation has been demonstrated in model organisms such as Drosophila melanogaster (Straub and Becker 2007; Gelbart and Kuroda 2009), recent transcriptome analyses showed that dosage compensation is highly variable across species(Mank et al. 2011).
Taking advantage of the vast amount of genetic data from the GWAS, our findings provide the first direct evidence that conserved pathways of aging simultaneously influence multiple age-related diseases in humans as has been demonstrated in model organisms.
Here, we have taken a novel approach to jointly analyzing a large set of GWAS data to directly address the question of whether human age-related diseases are linked by common underlying pathways of aging as has been demonstrated in model organisms.
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It has been demonstrated in models that coevolutionary clines may result from multiple effects [68].
The cost-effectiveness of nab-paclitaxel in MBC has also been demonstrated in model-based and retrospective analyses [ 22, 23].
It has been demonstrated in models of inflammation that the mechanisms of quercetin are related to inhibition of oxidative stress and cytokine production [ 23, 24].
There is unresolved controversy about whether direct carcinogenic effects of some oestrogen metabolites, which can clearly be demonstrated in model systems, also have a significant impact in women.
In vivo, the suppressive activity of adoptively transferred MDSCs could be demonstrated in models of inflammation [49] and cancer [50].
Likewise, immunotoxicity of PFCs has been demonstrated in rodent models, avian models, reptilian models, and mammalian and nonmammalian wildlife [ 19].
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