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While these techniques may be useful in analytical tools, they have not been demonstrated in continuous systems for processing large samples.
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We will now briefly describe two preliminary studies done in our laboratory to investigate whether multiple-look effects can be demonstrated in continuous sequences.
This has been demonstrated in vitro, where continuous exposure of O-BG alkylating drugs such as BCNU led to further upregulation of MGMT (and BCNU resistance) in MB cell lines (Bacolod et al, 2002, 2004).
44, 45 Depletion of MGMT has been demonstrated in vitro by cisplatin and continuous TMZ administration.
Although this clearly has been demonstrated in critically ill patients treated with continuous intravenous insulin (1), evidence regarding subcutaneous insulin in non critical-care settinon critical-care
Although improved cardiovascular stability during continuous veno-venous haemofiltration in comparison with intermittent dialysis has been demonstrated in retrospective studies [ 82], the superiority of continuous haemofiltration over hemodialysis on splanchnic circulation has not been proven [ 81].
Simultaneous fermentation of cellobiose and xylose by an engineered Saccharomyces cerevisiae has been demonstrated in batch fermentation, suggesting the feasibility of continuous co-fermentation of cellulosic sugars.
The benefits of real-time continuous glucose monitoring (CGM) have been demonstrated in patients with type 1 diabetes.
Accuracy of continuous thermodilution and SvO2 measurement has been demonstrated in vitro and at bedside.
Continuous outward polymerisation of microtubules from the microtubule organizing center (MTOC) towards the cell periphery has been demonstrated in the polarised, migrating cell [reviewed in [25]].
The proposed method is demonstrated in both simulations and experiments on continuous nonlinear mechanical structures.
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