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A leaky gut has also been demonstrated in cases of Parkinson's disease, multiple sclerosis, and Alzheimer's disease.
Disturbed placental epigenetics has been demonstrated in cases of intrauterine growth retardation and small for gestational age, and also appears to be involved in the pathogenesis of pre-eclampsia and gestational trophoblastic disease (reviewed in [69]).
The danger in the propagation of errors in scientific discourse has been demonstrated in cases of both scientific fraud as well as incorrectly described or referenced experiments in reviews [1], [2].
A persistent HIF1α expression has already been demonstrated in cases of lipopolysaccharide stimulation and during a sustained inflammatory response [ 25- 28].
In dogs, increased plasma levels of cTnI have been demonstrated in cases of toxaemia, babesiosis, myocarditis, and pericardial effusion and other heart diseases [ 10, 11, 14- 16].
Immediately initiating antibiotic therapy for the first GGS infection might contribute to the low level of immunity, as has been demonstrated in cases of recurrent GAS tonsillitis (28).
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This indicates that immortalization changes the responsiveness of keratinocytes to various stimuli, as it has been demonstrated in case of neuropeptides [63], [66].
It has already been demonstrated in case of various xenobiotics that higher doses for low time periods and lower doses for higher time periods can convert apoptosis into necrosis [41].
Finally, OD has been demonstrated in case reports after correction of acute (<48 h) hyponatraemia, so cautious correction is also important in these cases [ 42, 49].
Indeed, independent fusions of the same pairs of genes in diverse groups of eukaryotes as well as in eukaryotes and bacteria have been demonstrated in case studies (Yanai et al. 2002; Makiuchi et al. 2007).
Similar regulatory mechanism has been demonstrated in case of the human protein HYPE which shares structural and functional similarity with AMPylating enzymes found in pathogenic bacteria (Engel et al. 2012).
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