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This notion has recently been demonstrated in aged colonic crypt cells, where multimethod measurement of mtDNA mutation load failed to demonstrate an age-dependent increase (32).
A decrease in neuronal NOS and an increase in hippocampal iNOS have been demonstrated in aged rats [17], thus suggesting the dual roles of NO.
It has been demonstrated in aged brains that neurons, but not astrocytes, show upregulated autophagy [ 16].
Renal lesions also have been demonstrated in aged dogs [ 19, 21, 23].
Immunosenescence affects multiple aspects of the immune system, as has been demonstrated in aged humans and mice.
These have been demonstrated in aged brains in association with senile plaques and result from capillary bleeds or micro-haemorrhages [ 60, 107].
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In addition, the role of SIRT6 in genomic stability has been demonstrated in aging mouse models [ 84].
No significant differences were demonstrated in age at BO diagnosis between patients developing HGD/OAC and patients who died without developing HGD/OAC.
28, 31– 37 Recently, a high vaccine efficacy has also been demonstrated in women aged ≥26 years.
The immunogenicity of PCV13 has also been demonstrated in individuals aged 5 17 years.
Reduced inhibitory circuit activity might increase cortical activation during the performance of routine cognitive tasks, a phenomenon that has been demonstrated in the aging human prefrontal cortex by functional imaging studies [30], [31].
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