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For instance, a protective role for TLR3 has been demonstrated in a model of viral induced myocarditis.
Versican is thus also important for recruitment of monocytes, which has been demonstrated in a model of myocardial infarction.
Similar shifts of molecular clock peaks have been demonstrated in a model of experimental arthritis [ 23], which indicates that inflammation can directly interfere with rhythmicity of cells.
The muscle-protecting effect of EPO could be related to anti-apoptotic activity, as has been demonstrated in a model of cadiomyocyte ischemia [ 48].
In fact, a similar evolutionary mechanism has even been demonstrated in a model of random bimolecular rearrangements rather than ligation and cleavage reactions, thus extending the scope of the mechanism proposed here [ 19, 20].
A beneficial role of aggregation has been demonstrated in a model for Huntington disease, another neurodegenerative disease associated with trinucleotide repeats and intracellular protein aggregates, in which the unbound specimens are even more toxic than the aggregates.
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The general approach of combining guided STED with the original RESCue approach proved very efficient and could be demonstrated in a model system consisting of fluorescent beads mixed with reflective gold nanoparticles (Supplementary Movie 3).
Impaired oxidative balance was demonstrated in a model of Eimeria infection in chickens through evaluation of blood plasma oxidative stress markers [34].
This is demonstrated in a model shown in Figure 7, consistent with the observation that MSH2Y238F exerts a dominant negative effect on NPM-ALK-mediated p-Y of endogenous MSH2.
Similar effects could be demonstrated in a model of human skin, where sonicates of mast cells significantly increased fibroblast proliferation, collagen synthesis, and collagen contraction; surrogates for skin remodeling; and fibrosis (137).
Importantly, it has also been demonstrated in a mouse model that cytotoxic CD8+ T cells with reactivity toward hemagglutinin can specifically kill hypocretin neurons if these transgenically express hemagglutinin.
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