However, no channel function as been presently demonstrated either alone or in combination with other receptor subunits and available data point to a role in synapse development rather than functioning.
Recently, using a hamster model of infection, it has been demonstrated that either TcdA or TcdB alone, produced by isogenic mutants of C. difficile, may cause severe disease [ 14].
A stronger signal of reporter protein expression has been demonstrated when either KorA or KorB dimers are bound alone.
The feasibility of adding either a GLP-1RA to basal insulin therapy or a basal insulin analog to GLP-1RA therapy has been tested in several trials in which a potential for greater HbA1c reductions than with either therapy alone has been demonstrated [ 52– 52].
Although the superiority in efficacy of BPO/clin combination therapy over monotherapy of either drug alone has been demonstrated, the value of this in clinical practice needs to be considered by the practitioner as to whether this data in combination with other factors like cost, risks including bacterial resistance, and availability.
No survival advantage has been demonstrated for the patients receiving either type of adjuvant therapy compared with those undergoing surgery alone.
In a previous study, the combination of H:I and MGI was demonstrated to be superior to either index alone in predicting breast cancer recurrence risk in ER+ LN- breast cancer [ 7].
Furthermore, when human cartilage explants were incubated with IL-17A, TNF or OSM alone, mild proteoglycan depletion was observed; however, when IL-17A was combined with OSM or TNF, near complete proteoglycan depletion compared with either cytokine alone was demonstrated.
The sufficiency of ATRX inactivation, either alone or in combination with TP53 loss, to induce proliferative gliomagenesis has yet to be demonstrated.
were administered either alone or in combination for 7 days.
