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Several proteins have been demonstrated associated with the response of BR signaling.
In cells expressing mutSOD1, accumulation of phosphorylated p66Shc (on serine 36) has been demonstrated, associated with decreases in mitochondrial Ca2+ uptake capacity, ATP production, and mitochondrial integrity.
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Moreover, large multifunctional peptidase 2 (LMP2) rSNP587 SNP has been demonstrated to associate with AS radiographic severity [ 54].
In addition to energy modulation, AMPK has been demonstrated to associate with several important cellular events including inflammation.
Post-resuscitation hypocapnia has also been demonstrated to be associated with poor outcome [5, 6, 38].
The degree of hyperammonemia has been demonstrated to be associated with ICH [5].
ICU refusal due to bed unavailability has been demonstrated to be associated with increased mortality [17].
Angiogenesis also has been demonstrated to be associated with tumor progression, aggressiveness, and metastases.
Precuneus amyloid concentration has been demonstrated to be associated with disordered activity in Alzheimer's Disease [8].
Although the outcome "previous surgeries" has been demonstrated to be associated with worse surgical outcome [2, 10], collecting data on adhesions would have been interesting as well.
Hypocapnia and hypercapnia after ROSC have previously been demonstrated to be associated with poor outcomes in both adult and pediatric post-cardiac arrest patients [5, 6].
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