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Significant efficacy has been demonstrated across multiple solid tumour types within clinical trials.
However, when transferred using stringent training programs, in addition to standardized equipment and reagents, assay reproducibility has been demonstrated across multiple GCLP accredited laboratories [14], [15], [17], [24] supporting the role of core laboratories.
Adequate reliability and construct validity of the PCQ has been demonstrated across multiple samples [ 17].
Adequate reliability and validity of the subscale of the OSI-R have been demonstrated across multiple Chinese samples [ 36, 37].
The WOMAC Index is a disease-specific health status measure widely used in OA research, and its validity and reliability have been demonstrated across multiple settings.
β-Glucosidase activity has been demonstrated across multiple enzyme families within the glycoside hydrolase (GH) superfamily, including GH1, GH3, GH5, GH9, and GH30 (see CAZy database www.cazy.org) but has been most extensively characterized within the GH1 group of glycoside hydrolases.
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The involvement of neuronal changes in the central nervous system in the development of chronic pain was demonstrated across multiple studies.
The reproducibility of the assay was demonstrated across multiple biological replicates, and notable differences in phosphoprotein expression were observed between different cell lines.
Efficacy of KBU2046 is demonstrated across several different in vitro models and across multiple murine models of human cancer metastasis, which includes decreased metastasis, decreased bone destruction, and prolonged survival.
Significant genetic influences were demonstrated across measures.
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