This notion has also been corroborated in humans by our own and others findings that clinical improvement in SLE patients treated with rituximab correlates with B-cell depletion and precedes by several months any decline in serum levels of relevant autoantibodies [ 27].
In particular, dorsal premotor regions seem to connect predominantly to the superior parietal cortex and subserve reaching in space while more ventral aspects of the premotor cortex interact more strongly with the intraparietal sulcus for object manipulation, a finding that has more recently been corroborated in humans using diffusion tractography (Tomassini et al. 2007).
Single neuron recordings in monkeys during gripping and reaching tasks have demonstrated the role that PMv plays in preparing and executing movements (Hoshi and Tanji 2000, 2007), and this has been corroborated in humans using single neuron recordings (Ojakangas et al. 2006), TMS (Davare et al. 2006), and functional brain imaging (Coombes et al. 2010).
The ultimate value of [F]fluoro-PEG-folate for imaging of RA has to be corroborated in human studies, which is readily achievable since the current method for the synthesis of [F]fluoro-PEG-folate can easily be translated into a Good Manufacturing Practice compliant method yielding a clinical grade [F]fluoro-PEG-folate radiotracer.
The pathophysiological relevance of these divergent IgG effects was corroborated in human embryonic cardiomyocytes, using real-time impedance monitoring of the spontaneous beating rate as a readout of chronotropic effects and restricting the responsiveness of the model to β1AR-mediated regulation.
In addition, these experimental findings were corroborated in humans who suffered from AKI.
Their potential usefulness against radiation-induced mutagenesis of pre- and postexposure administration of phosphorothioates and other classes of protectors should be corroborated in humans.
The induction of cross-reactive antibodies to West Nile by JE vaccine was corroborated in humans (Yamshchikov et al. 2005), though whether the antibodies are protective remains to be seen.
Higher IgE levels among individuals exposed to lead have been corroborated in several human studies.
38 The size-dependent differences in axonal susceptibility to degeneration have since been corroborated in a human postmortem study using histochemistry.
