Sentence examples for been considerable difficulty from inspiring English sources

However, there has been considerable difficulty in developing an efficacious malaria vaccine, highlighting our incomplete understanding of immunity against this disease.

There have been considerable difficulties in recent years in recruiting and retaining paediatricians and social workers working at the very sharp-end of child protection.

But in fact he holds that there is considerable difficulty in making sense of the doctrine.

However, due to the complex interactions and overlap of anatomy and physiology, there is considerable difficulty associated with determining the contributions of structures involved.

However, standardized commercially available reagents do not exist, and there is considerable difficulty distinguishing closely related species [13].

However, in high-prevalence countries there may be considerable difficulty in using this technique, as an insufficient proportion of cases may be captured for testing [ 6].

Moreover, there is considerable difficulty in interpreting the published data regarding prehospital intubation, since the relevant studies frequently have very dissimilar populations that also receive dissimilar care.

There is considerable difficulty, however, in using HGVS for the well-known deletions including those found in the GJB6 gene (http://www.hgvs.org/mutnomen/uncertain.html exondel).html exondel

There are considerable difficulties with an "evidence-based" approach to bioethics, however, that require consideration.

He also warned him that there were "considerable difficulties" in justifying the use of force on self-defence grounds.

Banks reported no major problems today, and the financial markets were closed, masking what could be considerable difficulties whenever they reopen.