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The sharing of MHC alleles among populations also indicates that MHC alleles may have been conserved by selection [ 19].
A broader finding of our analysis is that less malaria intergenic sequence has been conserved by selection than in yeast or vertebrate genomes.
From a broader perspective, our results indicate that less malaria intergenic sequence has been conserved by selection than in yeast or vertebrate genomes.
DUX4 related sequences are found in primates and Afrotheria and we previously showed that they have been conserved by selection[ 1].
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That ~99.9% of boundaries are conserved thus suggests that a similar fraction are conserved by selection.
Microsatellites make up ∼3% of the human genome, and there is increasing evidence that some microsatellites can have important functions and can be conserved by selection.
Similarly, the fact that motif preferences are very similar even in mammals and Gallus is solid evidence that the empirical pattern of mammalian NBDM has been conserved by natural selection for a long time.
One possible explanation is that these cationic residues may have been selectively accumulated prior to the divergence of the studied bird lineages (~114 million years ago), and then have been conserved by negative selection through the long evolutionary history due to their significant role on peptide function.
It is natural to ask what protein properties have been conserved by the purifying selection.
A DNA or protein sequence motif is a short pattern that is conserved by purifying selection.
Homologs to the insect-specific proteins should be present in the ancestor and be conserved by natural selection.
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