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Searching for orthologs of the target genes in ArgR regulogs from RegPrecise (a regulog is defined as a set of coregulated genes for which the regulatory sequence has been conserved across multiple organisms [ 22]) and scanning with the ArgR DNA-binding motif in Clostridiales, several additional operons were identified as potentially also regulated by ArgR.
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The phylogenetic analysis indicated that putative homologues of Noc4p are present in many eukaryotic species and are conserved across multiple species (Fig. S1).
We estimate the number of genes in human gut, both the number of overall genes and the number of core genes, which are conserved across multiple microbes.
This is consistent with the notion that some genes are conserved across multiple regions that are interrogated by unique probes on the microarray, resulting in significantly more probes per probeset than random expectations.
Furthermore, we observed similar morphological defects following PI3K inhibition/absence in both MVA and WR infected cells, suggesting that the involvement of host PI3K is conserved across multiple poxviral species.
A group of similar stems which is conserved across multiple sequences is referred to as a stem block.
The RecQ family of helicases is conserved across multiple species and has been firmly linked to genomic maintenance [ 1– 3].
Four long forms and one super-short form splice variant from PDE4A are conserved across multiple species.
We also found a novel putative intron retention event (chr7:123269489–123270019, 531 bp) whose sequence is conserved across multiple vertebrate species.
Here, we attempted to elucidate whether transcriptional and/or translational patterns (termed themes) may be conserved across multiple cell types.
By contrast, local alignment is utilized to detect pathways or protein complexes that are conserved across multiple species.
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