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Recently, miRNAs have been confirmed to function in viral pathogenesis by regulating the expression of genes from both the viral and host genomes.
91– 95 Similarly, tamoxifen has been confirmed to function as a potent hepatocarcinogen, which may be a result of its DNA adduct-forming ability, and the lack of hepatocarcinogen ability of TOR may again result from its inability to form DNA adducts.
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If the putative substrate recognition proteins we identified can be confirmed to function in regulated proteolysis in vivo, it will be of interest to identify potential targets whose degradation might contribute to normal gastrulation.
However, its function has been confirmed to be distinct from that of animal CtBP [ 14].
TRP-N has been confirmed to be essential for many mechanosensory functions such as the control of body movement and the perception of touch in the fly (Effertz et al. 2011; Liang et al. 2013) and the nematode worm (Li et al. 2006), for maintaining equilibrium and hearing in zebrafish (Sidi et al. 2003), and it has also been localized in hair cells in the ear of frog (Shin et al. 2005).
ESP13.2, produced by macaque epididymis, was confirmed to have a function in the sperm capacitation process [51].
All control subjects were confirmed to have normal liver function, not to have viral hepatitis, and not to be alcoholics.
All control subjects were confirmed to have normal liver function and no viral hepatitis infection or alcoholics.
All control subjects (non-NAFLD) were confirmed to have normal liver function (aspartate aminotransferase (AST), alanine aminotransaminase (ALT) levels within normal range), no evidence of viral hepatitis and no evidence of the presence of criteria of the metabolic syndrome, such as diabetes mellitus and high serum cholesterol (see Table 1).
The functions of the i-th protein is represented as a label vector y i ∈ {0|1} C, where y ic = 1 if the i-th protein is confirmed to have the c-th function, otherwise, y ic = 0.
Once everolimus trough concentration was in the range 3 8 ng/mL, tacrolimus dose was tapered to achieve tacrolimus trough concentration of 3 5 ng/mL by week 3 after randomization, then tacrolimus elimination was started after everolimus trough concentration achieved 6 10 ng/mL at the start of month 4 posttransplant and if liver function was confirmed to be adequate (see the "Patients" section).
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