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CNVs have been confirmed to associate with Mendelian diseases and complex genetic disorders in humans, such as schizophrenia [ 15], body mass index [ 16], Crohn's disease [ 17] and intellectual disability and various congenital defects [ 18].
Background: Over 20 genetic risk factors have been confirmed to associate with elevated risk for Alzheimer's disease (AD), but the identification of environmental and/or acquired risk factors has been more elusive.
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ITPKC (rs28493229) was confirmed to associate with the susceptibility of Kawasaki disease and CAL formation.
Consistently, all three endogenous AMPK subunits (AMPKα, AMPKβ, and AMPKγ) were confirmed to associate with HA-ULK1 in 293 cells by co-immunoprecipitation analysis (Fig. 1A).
Chromatin:both of the top ranking proteins NSD1 and HRX (0.93), are methyltransferases and are confirmed to associate with chromatin (Berdasco et al., 2009; Guenther et al., 2005).
In keeping with previous data [ 17, 18], CXCL13 levels at baseline (before treatment) were confirmed to associate with clinical and laboratory measures of disease activity.
We speculate that a microbe which is confirmed to associate with field grown rice roots, such as EA105, may have better implications for rice protection compared to unrelated biocontrol isolates due to its ability to compete and survive in the rice rhizosphere.
Even if HCC risk was significantly lower in male patients with the miR-196a2 TT genotype or T allele than those with CC genotype or C allele [ 12], carriers of the miR-196a2 (rs11614913) T allele were confirmed to associate with susceptibility to HCC among Caucasian populations [ 15].
Long noncoding RNAs (lncRNAs) have been confirmed to be associated with various human diseases.
Glycosylation, which has been confirmed to be associated with many diseases, is an important protein post-translation modification.
NRXN1 has already been confirmed to be associated with SCZ.
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