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The adequacy of the cerebral function monitor has not been confirmed in critically ill patients because it is drug dependent [ 13].
The promising initial publications reporting the results of using serial serum PCT concentrations to guide duration of antibiotic therapy in patients with community-acquired pneumonia [ 9] have only partially been confirmed in critically ill patients.
The validity and reliability of the SF-36 has been confirmed in critically ill patients, and its use is validated in face-to-face interviews, telephone interview, and questionnaire by regular mail [ 32].
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The reliability observed in this study was good (Cohen κ index 0.83), but this agreement should be confirmed in critically ill patients.
The ability of PLR to serve as a test of preload responsiveness has been confirmed in additional studies performed in critically ill patients [40, 43, 45 51].
The ability of PLR to serve as a test of preload responsiveness has been confirmed in additional studies performed in critically ill patients [ 40, 43, 45- 51].
The clinical efficacy and the lack of toxicity of this regimen have been confirmed in a series of critically ill patients with bacteremia or VAP caused by MDR-GNB [ 24].
However, this has not been confirmed in a large group of critically ill patients.
Furthermore, since this finding was based on post hoc analyses, these observations need to be confirmed in other cohorts of critically ill patients.
This observation was confirmed in a group of critically ill multiple trauma patients, who showed variable and low heparin concentrations after subcutaneous injections [ 6].
Although the effects of the PBOXs on Bcr-Abl mutations in vitro is clear, these results needed to be confirmed in ex vivo patient samples, critically important in predicting a clinical response to potential anticancer drugs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com