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However, the effect of omega-3 fatty acid supplementation in reducing the risk of incident cancer has not been confirmed by randomized controlled trials and meta-analysis.
Parenteral administration of corticosteroids, epinephrine nebulization and inhalation of a helium/oxygen mixture are potentially effective, although this has not been confirmed by randomized controlled trials.
Several investigators proposed that NACT could improve the prognosis of cervical cancer [23], but this has not been confirmed by randomized trials [40].
While the safety and quality of inter-unit and hospital transfers appear to have improved over the years, the effectiveness of specific measures to improve safety have not been confirmed by randomized controlled trials.
Evidence is available for either condition, although the advantages of using blockers of the renin-angiotensin system in paroxysmal atrial fibrillation, supported as it is by pathophysiological data (favorable remodeling of left atrium value and wall structure) and post hoc analyses of randomized trials, have not been confirmed by randomized issue-specific trials (5).
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While a number of small studies show possible benefit from monolaurin, L-lysine, aspirin, lemon balm, topical zinc, or licorice root cream in treatment, these preliminary studies have not been confirmed by higher-quality randomized controlled studies.
The negative effect of the infused saline volume on kidney function has also been confirmed by two recent studies a retrospective one by Sen et al. [48] and the SMART randomized trial [49] involving critically ill patients.
Despite these promising findings, C1-INH will not be accepted for clinical practice unless it is confirmed by multicenter, randomized trials.
4 The current findings should be confirmed by a prospective, randomized controlled trial in older patients.
This combined approach has to be confirmed by a systematic randomized, controlled study.
If our results would be confirmed by a multicentre, prospective, controlled, randomized trial our protocol could be easily introduced in general practice not only for gastric washings in children with suspected TB but also for different kind of procedural sedation in uncooperative children.
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