Sentence examples for been complicated by problems from inspiring English sources

Further structural characterization of GPCRs has largely been complicated by problems with expression, purification, and preservation of activity in vitro.

However, the application of this technique to pachytene chromosomes has been complicated by problems in making preparations of meiotic chromosomes and by difficulties in the application of standard FISH protocols.

(Interestingly, there's also some evidence that the divorce rate stopped falling over the last decade, though this is complicated by problems with the data sources that I'm not competent to adjudicate).

The use of occupational cohort studies to assess the association of benzene and lymphoma is complicated by problems with exposure misclassification, outcome classification, and low statistical power.

It will be a practical matter to determine the extent to which the Stewart approach will be complicated by problems in computing both SID and weak acids in urine.

A small study has indicated that an early increase in apoptosis as measured in fine-needle aspirates (FNA) by flow cytometry was significantly associated with clinical response in breast cancer, but this methodology was noted to be complicated by problems of precision (Chang et al, 1999).

His preparation for the London Games has been complicated by foot problems, disappointing tuneup races and an acknowledgment that his initial training strategy — to try to shatter the world record — did not work.

Detection of DCA production in vivo after TCE administration has been complicated by reported problems with analytical methodologies that have led to artifactual formation of DCA ex vivo when samples contain significant amounts of TCA (Ketcha et al. 1996).

To date, the inheritance patterns have been complicated by the problem of integrating epigenomic and transcriptomic factors that have yet to be elucidated.

The American stance toward the region's problems has been complicated by bad feelings set off by comments made on Sunday by Mr. O'Neill.

The company, I-Lite Electric of Manhattan, is one of several under investigation for allegedly defrauding the agency, whose financial problems have been complicated by cost overruns on building projects.