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They have not yet been completely validated in terms of their ability to predict the outcome of trials; however, as discussed in this Review, there is extensive evidence of their relevance in preclinical research (Singh et al., 2010).
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The role of ATP7A in development of platinum resistance in S3 cells, however, could not be completely validated in our growth-inhibition assays with pretreatment with sodium orthovanadate and ATP7A-targeted siRNA (Table 3 and Figure 4B).
They however point out that there is still no MRI-based methodology that has been completely validated as suitable for integration in clinical routine.
However, biomarkers that have been completely validated during Phase II for use in Phase III trials are often unavailable [ 11, 12].
Grading is determined in clinical, imaging, operative, and pathologic categories, but has not been completely validated.
The optimized chromatographic method was completely validated according to the procedures described in ICH guidelines Q2 (R1) for the validation of analytical methods.
The finding suggests that the mentioned method was completely validated and successfully applied for the determination of IDA in real samples such as serum.
Annotation of microarray platforms has improved greatly over the past several years, but errors in annotation will continue to affect analyses until genomes are completely validated and curated.
This test was completely validated and submitted to a rigorous QA/QC protocol.
This could be completely validated by the DSO report confirming these 23 hospitals as the actual liver transplantation centres in Germany which all fulfilled the minimum volume standard.
It was a beautiful, contrite letter that was completely validating.
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